Cologuard ® Frequently Asked Questions

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What is Cologuard?

What is Cologuard?

Cologuard is an FDA-approved, non-invasive, at-home colon cancer screening test. It’s for people 45 or older at average risk for colon cancer. RX only.

Why does screening matter?

Colon cancer is the most preventable, yet least prevented cancer. 1 But when caught in early stages (I & II), it’s treatable in about 90% of people. 2

What does Cologuard screen for?

Cologuard detects the DNA and blood released from altered cells, and can detect both precancer and cancer.

How does Cologuard work?

Cologuard uses advanced stool technology to detect the DNA and blood cells released from altered cells, and can detect both precancer and cancer.

How effective is Cologuard?

Cologuard found 92% of all colon cancers (and 94% of all stage I & II cancers) in a clinical study of 10,000 participants ages 50-84 years old, of average risk for colorectal cancer.

Can Cologuard detect polyps?

Yes, Cologuard can detect some precancerous polyps that grow on the wall of the colon and may develop into cancer.

Who is Cologuard for?

Cologuard is for adults 45 years of age and older who are at average risk for colon cancer. Cologuard is not a replacement for colonoscopy in high-risk individuals.

Is Cologuard FDA-approved?

Yes, Cologuard was approved by the FDA in August 2014 after undergoing a rigorous review process known as a Pre-Market Approval (or PMA).

How To Use Cologuard

How do I get Cologuard?

You can request Cologuard through your healthcare provider. Requesting Cologuard through an online telehealth provider is also an option.

How do I use Cologuard?

Your Cologuard test kit comes with easy-to-follow, step-by-step sample-collection instructions. You can also Download our Patient Guide or watch Helpful How-To Videos.

Is there any prep required to use Cologuard?

There is no prep required to use Cologuard. You can keep your diet and your medications exactly as they are.

Where do I go to track my Cologuard order?
Log in to your personal account to track your order.
How do I return my Cologuard kit?

Your Cologuard test kit includes simple instructions for repacking, labeling, and postage (which we cover) to return your sample. You can also Download Return Instructions or watch a Helpful How-To Video.

I received my Cologuard kit a while ago and haven’t used it yet. How long is it good for?

Your test order expires one year from the order date. Collect your sample as soon as possible, because timely screening is important to your health. We suggest setting a goal to collect your sample.

Also, check the Cologuard box for the expiration date. If that date has passed, or you have other questions, call Customer Care at 1-844-870-8870. We can help you get a new Cologuard test kit at no additional cost.

How can I tell if my stool sample is “normal”?

It’s important that your sample is consistent for you (loose stools are ok if that’s normal for you). However, if you are sick and have diarrhea, you should wait until you feel better to collect a sample. If you have any questions, call Customer Care at 1-844-870-8870.

I received my Cologuard kit, but I made a mistake collecting my sample. What should I do?

We’re here to answer any questions you may have 24/7. Just call Customer Care at 1-844-870-8870. If needed, we can get you a new Cologuard test kit at no additional cost.

I received my Cologuard kit but it’s damaged or missing a part. What should I do?

Call our Customer Care Center at 1-844-870-8870. We'll help you find out if you need a new Cologuard test kit. If you do, we'll send you one at no additional cost.

How often should you use Cologuard?

The American Cancer Society recommends that you begin screening for colon cancer at age 45 – no matter your race, ethnicity, or gender. If you receive a negative result, it's recommended that you screen again in 3 years.

Managing Results

When will I get my screening results?

It typically takes under 2 weeks from the date you ship back your Cologuard kit to get your result. We’ll send them to your healthcare provider too so you can discuss your result with them.

Where do I access my test results?

Log in to your account to access your results. It typically takes under 2 weeks from the date you ship back your Cologuard kit.

What does a positive result mean?

A positive result means the test detected altered DNA and/or blood that could be caused by a precancerous polyp or colon cancer. Talk to your healthcare provider about getting a colonoscopy, and any other next steps.

What does a negative result mean?

A negative result means the test did not detect altered DNA and/or blood that could be caused by a precancerous polyp or colon cancer. We send your result to your provider regardless and recommend following up with them.

What percentage of positive Cologuard tests are cancer?

A positive Cologuard test result is not a cancer diagnosis. If you receive a positive result, contact your doctor to discuss next steps.

What percentage of people get a false positive?

Cologuard is intended to screen adults 45 and older at average risk for colon cancer. In a study of 10,000 people of average risk, Cologuard found 92% of cancer. Cologuard was negative in 87% of patients without cancer. A positive result is not a cancer diagnosis. Contact your healthcare provider to discuss your results and next steps.

You should always talk to your doctor about what colon cancer screening method is right for you. Cologuard ® offers a noninvasive, convenient and effective test that can be completed right in your home.

If you have any questions, please contact Exact Sciences Customer Care at 1-844-870-8870 .

Billing & Insurance

Is Cologuard covered by insurance?

Cologuard is covered by Medicare, Medicaid, and most major insurers. Most insured patients pay $0.00 *

How much does Cologuard cost?

Most insured patients pay $0.00 * . However, there are some instances where Cologuard is only partially covered, or not at all. The rate of coverage varies by state, region, and your insurance plan. If you’re struggling to get Cologuard covered, give our Customer Care Center a call at 1-844-870-8870 and we’ll call your insurance provider ourselves to see if we can help.

Does insurance cover colonoscopy after Cologuard?

As of 2023, Medicare and commercial plans cover the out-of-pocket cost for a colonoscopy following a positive Cologuard result. Exceptions for coverage may apply; please confirm with your insurer. They are the best source of info on your plan and coverage.

How do I pay a Cologuard bill?

Cologuard accepts payment either online or by mail. For assistance call our Customer Care Center at 1-844-870-8870.

How does requesting Cologuard online work?

You can request Cologuard online through a telehealth provider. Exact Sciences partnered with Recuro Health to offer this telehealth service. You just need to answer a few questions to get started.

Who is Recuro Health?

Recuro Health is a telehealth company. Exact Sciences partnered with Recuro Health to offer telehealth services. This allows you to request Cologuard online.

I am not going to use this. Do I just send it back? Will my insurance be billed?

Please discuss your colon cancer screening plan with your healthcare provider. If you choose not to screen for colon cancer with Cologuard ® , you may simply recycle the components of the kit. There is no charge until a sample is received and processed. You may receive some reminders in the meantime, and if you wish not to, please contact Exact Sciences Customer Care at 1-844-870-8870.

Additional Questions

Why did I receive a Cologuard kit from Exact Sciences in the mail?

If you received a Cologuard test in the mail, it means your insurance or healthcare provider requested it on your behalf. Adults aged 45 and older at average risk for colon cancer are eligible for testing. If you have additional questions about this order, please contact Exact Sciences Customer Care at 1-844-870-8870. The team is available 24/7 and will be able to help.

Is Cologuard available in all US states?

Cologuard is available in all US states. If you have more specific questions, please contact us at 1-844-870-8870.